Immunological aspects of nephrotic syndrome in northern Nigeria.

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Immunological aspects of nephrotic syndrome in northern Nigeria.

Immunological aspects of 40 northern Nigerian children with nephrotic syndrome of recent onset are reported. Eight our of 30 had hepatitis-associated antigen in their sera. Hypocomplementaemia was rare. Measurement of serum C3, C4, and ASOT was not of diagnostic value. Proteinuria selectivity index was poor in half of the patients, and appeared t o depend on the severity of the kidney lesion. A...

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One hundred and thirty-five adult patients admitted into the medical wards with the nephrotic syndrome have been studied over a period of 3 years. The histopathology in eighty-one renal biopsies showed predominantly proliferative glomerulonephritis. Nine patients had filariasis and in six of these the microfilaria isolated was Loa loa. Six patients had malarial parasitaemia; of these, three had...

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Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia. Minimal change nephrotic syndrome (MCNS) is the most common form of INS in children. The pathogenesis of MCNS still remains unclear, however, several hypotheses have been recently proposed. For several decades, MCNS has been considered a T-cell disorder, which causes the impairment of th...

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ژورنال

عنوان ژورنال: Archives of Disease in Childhood

سال: 1981

ISSN: 0003-9888,1468-2044

DOI: 10.1136/adc.56.3.199